Setyah Sultrasari Darman  

Jurusan Kedokteran Gigi, Fakultas Kedokteran, Universitas Jenderal Soedirman   

Fani Tuti Handayani 

Jurusan Kedokteran Gigi, Fakultas Kedokteran, Universitas Jenderal Soedirman

Bambang Tri Hartomo  

Jurusan Kedokteran Gigi, Fakultas Kedokteran, Universitas Jenderal Soedirman   

Setiadi Warata Logamarta 

Jurusan Kedokteran Gigi, Fakultas Kedokteran, Universitas Jenderal Soedirman

Dwi Nur Indah Sari 

Jurusan Kedokteran Gigi, Fakultas Kedokteran, Universitas Jenderal Soedirman

DOI: https://doi.org/10.19184/stoma.v21i1.47328

ABSTRACT 

Osteoblasts are important for orthodontic tooth movement because they influence the activity of bone formation on  the  tension  area.  The  administration  of  natural  ingredients  such  as  black  cumin  is  proven  to  increase  the  number  of osteoblasts because it contains thymoquinoneas antioxidants to accelerate the process of tooth movement. The study aims to  determine  the  differences  in  osteoblast  count  and  their  effect  on  the  orthodontic  movement  of  teeth  after  oral administration of black cumin. The method used in this research is experimental laboratory in vivo with a randomizedpost-test only control group design using 16 male Sprague-Dawley rat samples that were devided into four groups: the control group (K) with distilled water for 7 and 14 days, also the treatment group (P) with black cumin (Nigella sativa) for 7 and 14 daysElastomeric separators were placed on the upper jaw central incisors (right central incisor) using a separator applier to provide orthodontic mechanical  force  conditions.Alveolar  bone  tissue  samples  were  taken  after  treatment  then  the  number  of  osteoblasts  was calculated histologically. Data were anaylzed using One Way Anova Test and LSD (p<0.05). Result of this research indicated that there was an increase in the number of osteoblasts in orthodontic movement after oral administration of black cumin.