Perbandingan Efektivitas Antara Ekstrak Kulit dan Buah Delima Merah (Punica granatum Linn) Terhadap Penyembuhan Kandidiasis Oral Tikus Wistar
(Comparison of the Effectiveness Between Peel Extract and Grains Red Pomegranate (Punica granatum Linn) in Curing of Oral Candidiasis Wistar Rats
Embedded Files
Sri Hernawati, Ayu Mashartini Prihanti, Leni Rokhma Dewi
Bagian Ilmu Penyakit Mulut, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia
Refina Dikta Eryananda
Kedokteran Gigi, Fakultas Kedokteran Gigi, Universitas Jember, Indonesia
DOI: https://doi.org/10.19184/stoma.v20i2.44021
ABSTRACT
Oral candidiasis is a fungal infection that occurs in the oral mucosa caused by the growth of Candida albicans. One of the antifungal drugs that are widely used by the public is nystatin. Nystatin is an effective drug because of its low toxicity level, butcan cause side effects such as nausea, vomiting, diarrhoea, stomach pain, and resistance. In order to minimize these side effects, natural ingredients from red pomegranate can be used which have antifungal active ingredients in it. To compare the effectiveness of the whole extract with the skin of the red pomegranate (Punica granatum Linn) on the healing of oral candidiasis in Wistar rats. This research is a laboratory experimental study with a post-test only control group design. The samples used were 24 male wistar rats which were divided into 4 groups, namely (P1) the red pomegranate extract group with a concentration of 75%, (P2) the red pomegranate peel extract group with a concentration of 75%, (K+) the nystatin group, and (K -) the group that was notgiven anything. Microbiological examination and clinical examination (supporting examination).The data were analyzed using the Kruskal-Wallis non-parametric analysis test, the data before the extract and control showed no significant difference between each group (p>0.05) and the data after the extract and control administration showed there was a significant difference between each group. (p<0.05). Based on the Mann-Whitney test showed that red pomegranate extract and red pomegranate peel extract had a significant difference (p<0.05). Red pomegranate extract (Punica granatum Linn) at 75% concentration was more effective than red pomegranate skin extract (Punica granatum Linn) at 75% concentration on oral candidiasis treatment in wistar rats.
Published
31-10-2023
Issue
Vol. 20 No. 2 2023: Jurnal Stomatognatic
Pages
172-179
License
Copyright (c) 2023 Jurnal Stomatognatic
Page updated
Report abuse